STAT 5 Is Critical To Maintain Effector CD

+ STAT 5 Is Critical To Maintain Effector CD 8

+ STAT 5 Is Critical To Maintain Effector CD 8 Finkelman

During an immune response, most effector T cells die, whereas some are maintained and become memory T cells. Factors controlling the survival of effector CD4 + and CD8 + T cells remain unclear. In this study, we assessed the role of IL-7, IL-15, and their common signal transducer, STAT5, in maintaining effector CD4 + and CD8 + T cell responses. Following viral infection, IL-15 was required to m...

Stat 6 Type 2 Immune Responses Is Negatively Accumulation of Effector CD 4 T Cells during

بررسی تعداد سلول‌های T تنظیمی در بیماران مبتلا به بیماری کرون

Background and purpose: Crohn disease (CD) is an autoimmune disorder in which a failure of tolerance to the intestinal antigens plays a pivotal role in the pathogenesis of this disease. Treg cells control immune responses to self and foreign antigens and have an important role in maintaining self-tolerance. In this study we evaluated the frequency of Tregs in the peripheral blood of patients wi...

COELIAC DISEASE Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa

Background: In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. Aims: To analyse expression of transcription factors which control the Th1 cell commitment in CD. Patients: Duodenal mucosal samples were taken from untr...